Pediatric anesthesia & critical care
Age-Stratified Propofol Dosage for Pediatric Procedural Sedation and Analgesia
Authors' conclusion
We found a noteworthy inverse age-effect on propofol dosage for both induction and maintenance of pediatric procedural sedation.
Study context
- Population
- Children receiving procedural sedation and analgesia with propofol at a tertiary pediatric hospital (Wilhelmina Children's Hospital, University Medical Center Utrecht (UMCU)), June 2007–December 2020
- Participants
- 6,438 procedures
- Outcome
- Age dependence of propofol induction (mg·kg −1 ) and maintenance (mg·kg −1 ·h −1 ) dosage
Methodological detailssingle-centre, multivariable linear regression
- Single-centre
- Multivariable linear regression
Main finding
As reported in the abstract
Propofol dosage per year of age (adjusted coefficient)
Coefficient
−0.11
95% CI −0.12 to −0.11
Induction dosage (mg·kg −1 ) per year of age · 5567 records analysed
Coefficient
−0.36
95% CI −0.39 to −0.34
Maintenance dosage per year of age · 5420 records analysed
Observational data: associations, not effects.
Original publication
Age-Stratified Propofol Dosage for Pediatric Procedural Sedation and Analgesia. Anesth Analg. Published 17 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →