Respiratory failure & ventilation
Air Hunger Far Exceeds Dyspnea Sense of Effort during Mechanical Ventilation and a Weaning Trial
Authors' conclusion
Patients developed increases in dyspnea and PtcCO2 but unchanged [Formula: see text]e and work of breathing during an unassisted-breathing trial; patients selected air-hunger descriptors overwhelmingly over excessive effort.
Study context
- Population
- Patients receiving prolonged ventilation (>21 d) after recovering from critical illness26 in unassisted-breathing trial
- Participants
- 27 patients
- Outcome
- Dyspnea during 60-min unassisted-breathing trial
Methodological details60-minute unassisted-breathing trial
- 60-minute unassisted-breathing trial
Main finding
As reported in the abstract
- Increase in dyspnea during the trial
- P < 0.01
- Increase in PtcCO2 during the trial
- P < 0.01
- Dyspnea score linked to PtcCO2
- P < 0.012
- Dyspnea score linked to airway resistance
- P < 0.013
- At 60 min, "Not getting enough air" alone or with "Too much effort"
- 83.3%
- At 60 min, "Too much effort" alone (P < 0.001)
- 16.7%
- Across the dyspnea spectrum, "Not getting enough air" chosen overwhelmingly over other descriptors
- P < 0.001
Observational data: associations, not effects.
Further findings
Dyspnea during assist-control ventilation
- Patients reporting dyspnea
- 10
- Of these, selected "Not getting enough air": 9
- 90.0%
- Vt setting lower in dyspneic vs nondyspneic patients (480.0 vs. 559.4 ml)
- P < 0.046
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Air Hunger Far Exceeds Dyspnea Sense of Effort during Mechanical Ventilation and a Weaning Trial. Am J Respir Crit Care Med. Published 1 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →