Respiratory failure & ventilation
Airway epithelium damage in acute respiratory distress syndrome
Authors' conclusion
The airway epithelium from patients with ARDS exhibits multifaceted alterations leading to altered mucociliary differentiation, compromised defense functions and increased permeability with pneumoproteinemia.
Study context
- Population
- Patients with ARDS and controls (lung tissue samples; serum and broncho-alveolar lavage fluid (BALF))
- Comparison
- ARDS vs controls
- Outcome
- Epithelial alterations in the distal airways
Methodological detailsretrospective tissue analysis, prospective serum and BALF collection, multiplex fluorescence immunostaining, computer-assisted quantification
- Retrospective tissue analysis
- Prospective serum and BALF collection
- Multiplex fluorescence immunostaining
- Computer-assisted quantification
Main finding
As reported in the abstract
Airway epithelial alterations in ARDS vs controls
- No change in cell progenitors (basal and club cells)
- ARDS vs Controls: P = 0.0003
- ARDS vs Controls: P = 0.0005
- ARDS vs Controls: P = 0.0317
- ARDS vs Controls: P = 0.056
- ARDS vs Controls: P < 0.0001
- ARDS vs Controls: P = 0.025
- ARDS vs Controls: P < 0.0001
Further findings
| Outcome | P value |
|---|---|
| Serum and BALF lung-derived proteinsSerum secretory component (SC) and S-IgA increased (both) | P < 0.0001 |
Serum and BALF lung-derived proteins
- Serum CC16, SP-D, sRAGE also increased in ARDS
- BALF concentrations unchanged
Original publication
Airway epithelium damage in acute respiratory distress syndrome. Crit Care. Published 30 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →