Respiratory failure & ventilation
Integrative multi-omics analysis unravels the host response landscape and reveals a serum protein panel for early prognosis prediction for acute respiratory distress syndrome (ARDS)
Authors' conclusion
This study unveiled several novel predictive biomarkers and established a validated prediction model for the poor prognosis of ARDS, offering valuable insights into the prognosis of individuals with ARDS.
Study context
- Population
- Adults at the initial stage of ARDS, with disease and healthy controlsdiscovery and validation cohorts
- Comparison
- Protein-based model vs clinical model for 28-day ARDS prognosis
- Outcome
- 28-day prognosis of ARDS
- Follow-up
- 28 days
Methodological detailsdiscovery and external validation cohorts, 4D-DIA proteomics and global metabolomics, parallel reaction monitoring (PRM) targeted mass spectrometry validation, machine learning, Validation cohort: 183 patients, Discovery cohort: 130 ARDS patients, 33 disease controls, 33 healthy controls
- Discovery and external validation cohorts
- 4D-DIA proteomics and global metabolomics
- PRM targeted mass spectrometry validation
- Machine learning
- Validation cohort: 183 patients
- Discovery cohort: 130 ARDS patients, 33 disease controls, 33 healthy controls
Performance
As reported in the abstract
Predictive accuracy for poor prognosis (AUC)
AUC
0.893 vs. 0.784
P < 0.001
discovery cohort; Delong test
AUC
0.802 vs. 0.738
P = 0.008
validation cohort; Delong test
Further findings
Mechanistic pathways in ARDS
- Upregulated sphingolipid signaling pathway key in ARDS; MAP2K1 hub protein
- S1P closely associated with ARDS and its prognosis
- Deceased ARDS: downregulated hematopoietic cell lineage and calcium signaling; upregulated unfolded protein response and glycolysis
- GAPDH and ENO1 highest interaction degree in protein-protein interaction network
Candidate biomarkers
- Candidate protein biomarkers in discovery cohort
- 36
- Proteins consistent in validation cohort (PRM)
- 8
Original publication
Integrative multi-omics analysis unravels the host response landscape and reveals a serum protein panel for early prognosis prediction for ARDS. Crit Care. Published 2 July 2024. doi:10.
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