Respiratory failure & ventilation
Airway pressure release ventilation (APRV) versus pressure support ventilation (PSV)—A prospective intervention trial comparing haemodynamic parameters in intensive care patients
Authors' conclusion
We could not detect any changes in cardiac index in ICU patients without severe lung disease during APRV compared to PSV mode, despite lower peak airway pressure and increased mean airway pressure.
Study context
- Population
- Intubated, mechanically ventilated adult intensive care unit (ICU) patients without severe lung disease, triggering and stable on PSV, with pulse-induced continuous cardiac output (PiCCO) monitoring
- Participants
- 20 participants
- Exposure
- APRV vs PSV
- Outcome
- Cardiac index
- Follow-up
- End of each 30-min interval
Methodological detailssingle-centre, crossover (PSV–APRV–PSV, 30-min intervals)
- Single-centre
- Crossover (PSV–APRV–PSV, 30-min intervals)
Main finding
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Change (mmHg) | P value |
|---|---|---|
| Central venous pressureSignificant increase | +1.0 | P = 0.027 |
Peak airway pressure
- Significant reduction in peak airway pressure
- −3.16 cmH2O, p < .01
Mean airway pressure
- Increase in mean airway pressure
- +2.1 cmH2O, p < .01
Oxygenation index (pO2/FiO2) and other secondary outcomes
- No statistically significant change, PSV vs APRV
Association of global end-diastolic volume index with cardiac index and central venous pressure
- No significant association with cardiac index
- R2 = 0.0089
- No significant association with central venous pressure
- R2 = 0.278
Return to PSV
- All parameters returned to baseline after switching back to PSV
Original publication
Airway pressure release ventilation (APRV) versus pressure support ventilation (PSV)—A prospective intervention trial comparing haemodynamic parameters in intensive care patients. Acta Anaesthesiol Scand. Published 19 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →