Cardiothoracic & vascular anaesthesia
Acute Kidney Injury after Cardiac Surgery for Infective Endocarditis: AKICSIE study
Authors' conclusion
Postoperative AKI affects nearly half of patients undergoing surgery for IE. Preoperative nephrotoxic drug exposure and red blood cell transfusion were the only modifiable risk factors identified.
Study context
- Population
- Adults who underwent cardiac surgery for infective endocarditis (IE), 2013–2023of 1,359 IE surgery patients
- Participants
- 750 adults
- Outcome
- Risk factors for AKI onset or progression after cardiac surgery for IE
Methodological detailsmultivariable analysis
- Multivariable analysis
Main finding
As reported in the abstract
Independent risk factors for postoperative AKI (pre- and intraoperative variables)
- Postoperative acute kidney injury (AKI) incidence: 362 patients
- 48.3%
- Older age, OR [CI]
- 1.023 [1.010-1.036]
- Higher EuroSCORE II, OR [CI]
- 1.029 [1.014-1.045]
- RBC transfusion, OR [CI]
- 1.119 [1.074-1.166]
- Multivalvular involvement, OR [CI]
- 1.876 [1.198-2.936]
- Preoperative nephrotoxic agents, 2-3 drugs vs ≤1, OR [CI]
- 1.798 [1.194-2.708]
- Preoperative nephrotoxic agents, ≥4 drugs vs ≤1, OR [CI]
- 3.699 [1.806-7.578]
Observational data: associations, not effects.
Further findings
6-month mortality by renal recovery
- No renal recovery
- 36.9%
- Renal recovery
- 5.6-8.5%
- P
- P < 0.001
Major adverse kidney events (469 with 6-month renal follow-up)
- Overall
- 29.9%
- No AKI
- 16.2%
- KDIGO stage 3
- 67.5%
- Trend with AKI severity, P
- P < 0.001
Original publication
Acute Kidney Injury after Cardiac Surgery for Infective Endocarditis: AKICSIE study. Anaesth Crit Care Pain Med. Published 24 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →