Albumin use in patients with septic shock—Post‐hoc analyses of an international randomised fluid trial
Primary result · Associations with albumin use during ICU stayResult — go to the resultHazard ratio 2.58 95% CI 1.89–3.53Authors' conclusion
In adults with septic shock, gastrointestinal focus of infection and higher doses of norepinephrine at baseline were associated with albumin use, which also varied substantially between sites.
Study context
- Population
- Adults with septic shock in the CLASSIC trial1,541 analysed
- Participants
- 1,554 adults
- Comparison
- Associations of baseline variables and trial site with albumin use during ICU stay
- Primary endpoint
- Albumin use during ICU stay
- Follow-up
- ICU stay
Methodological detailspost-hoc, international, competing-risks Cox models
- Post-hoc
- International
- Competing-risks Cox models
Primary result
Associations with albumin use during ICU stay · During ICU stay
Hazard ratio
2.58
95% CI 1.89–3.53
Highest quartile of norepinephrine doses
HR 2.58 (95% CI 1.89–3.53)
As reported in the abstract
- HRs for site vs albumin use ranged from
- 0.11 (95% CI 0.05 to 0.26) to 1.70 (95% CI 1.06 to 2.74)
- Test for overall effect of site
- P < 0.001
Original publication
Albumin use in patients with septic shock—Post‐hoc analyses of an international randomised fluid trial. Acta Anaesthesiol Scand. Published 17 November 2023. doi:10.
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