Effects of IV Fluid Restriction According to Standard Fluid Treatment Intensity Across Conservative Versus Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care (CLASSIC) Trial Sites
Authors' conclusion
Among adult ICU patients with septic shock, variation in standard IV fluid volumes across sites did not substantially impact the effects of fluid restriction on outcomes after accounting for patient characteristics.
Study context
- Population
- Adult ICU patients with septic shock in CLASSIC trial sites with ≥15 participants in the standard-fluid group
- Participants
- 1,366 patients · 19 sites
- Comparison
- Restrictive vs standard IV fluid therapy across site intensity subgroups
Methodological detailsmachine learning (eXtreme Gradient Boosting), hierarchical Bayesian models with weakly informative priors, site-level sensitivity analyses
- Machine learning (eXtreme Gradient Boosting)
- Hierarchical Bayesian models with weakly informative priors
- Site-level sensitivity analyses
Primary result
As reported in the abstract
Mortality across five site intensity subgroups (subgroup) · day 90
Absolute differences in mortality across subgroups ranged from
−2.7% point to 1.4% point
Further findings
- Administered minus predicted IV fluid volume, standard-fluid group · first 24 hours
- −118 · median · IQR −1,341–1,731 · mL
Site-level sensitivity analyses
- Results similar in the sensitivity analyses
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effects of IV Fluid Restriction According to Standard Fluid Treatment Intensity Across Conservative Versus Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care (CLASSIC) Trial Sites. Crit Care Med. Published 24 April 2025. doi:10.
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