Effects of IV fluid restriction according to site‐specific intensity of standard fluid treatment—protocol
Study context
- Population
- Critically ill adults with septic shock in ICU
- Planned comparison
- IV fluid restriction vs standard fluid treatment, by site-specific intensity of standard fluid treatment
- Primary endpoint
- All-cause mortality
- Follow-up
- 90 days
Methodological detailsheterogeneity in treatment intensity analysis, hierarchical Bayesian regression, machine learning (extreme gradient boosting) prediction model, Prediction model with 22 baseline predictors, Secondary outcomes: serious adverse events or reactions, days alive without life support, days alive out of hospital at 90 days, Posterior distributions of RR, ratios of means, risk differences and MD presented per subgroup
- Heterogeneity in treatment intensity analysis
- Hierarchical Bayesian regression
- Machine learning (extreme gradient boosting) prediction model
- Prediction model with 22 baseline predictors
- Secondary outcomes: serious adverse events or reactions, days alive without life support, days alive out of hospital at 90 days
- Posterior distributions of RR, ratios of means, risk differences and MD presented per subgroup
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Effects of IV fluid restriction according to site‐specific intensity of standard fluid treatment—protocol. Acta Anaesthesiol Scand. Published 4 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →