An Examination of Organ Donor Hemodynamic Variation and Warm Ischemic Times Stratified by Functional Thresholds
Authors' conclusion
Our findings suggest fdWIT criteria may not be equivalent, and that fdWITs alone may not sufficiently reflect physiologic processes that could lead to graft injury.
Study context
- Population
- ICU patients undergoing withdrawal of life support measures (organ donation after death determination by circulatory criteria)
Primary result
As reported in the abstract
Hemodynamic and ischemic variation of fdWIT
- After withdrawal, SpO2 and BP thresholds for functional donor warm ischemic time (fdWIT) met sequentially in a predictable manner: SpO2 criteria first, then BP criteria
- Determination by circulatory criteria (DCC) Ischemic Index (DCC Ischemic Index (DII)) can capture hemodynamic fluctuations, potentially an improved method to quantify ischemic graft injury
- Inflammatory cytokine release may be more correlated with DII than with fdWIT
Original publication
An Examination of Organ Donor Hemodynamic Variation and Warm Ischemic Times Stratified by Functional Thresholds. Crit Care Med. Published 2 April 2026. doi:10.
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