Cardiothoracic & vascular anesthesia
An Observational Study of Changes in Renin Concentrations and Associations With Complications Following Cardiac Surgery
Main finding · Cumulative renin concentrations over 24 h, any postoperative complication vs noneResult — go to the resultMedian difference 1887 mIU L-1 CI 908–6177Authors' conclusion
Haemodynamic compromise, but not postoperative complications overall, were associated with serial plasma renin concentrations during the first 24 h of ICU admission following cardiac surgery.
Study context
- Population
- Patients admitted to ICU following cardiac surgery
- Participants
- 104 patients
- Outcome
- Composite incidence of postoperative complications (AKI, acute MI, shock, acute respiratory failure, new onset atrial flutter/fibrillation, cerebrovascular accident) in relation to plasma renin concentrations
Main finding
As reported in the abstract
Cumulative renin concentrations over 24 h, any postoperative complication vs none · 24 h
Median difference
1887 mIU L-1
CI 908–6177
P = 0.04
Any postoperative complication vs No complication
median difference 1887 mIU L-1 (CI 908–6177); P = 0.04
- Patients meeting at least one diagnostic criterion for postoperative complications
- 54 (52%)
Observational data: associations, not effects.
Further findings
| Outcome | Median difference (mIU L-1) (CI) | P value | |
|---|---|---|---|
| Cumulative renin over 24 h, haemodynamically unstable vs stable | 1296 (54–2943) | P = 0.04 | |
| −2000020004000Difference, mIU L-1 (linear scale) |
Plasma renin concentrations over time
- Renin on ICU admission (mIU L-1)
- 130 [34-445]
- Renin at 6 h (mIU L-1)
- 119 [35-447]
- Renin at 24 h (mIU L-1)
- 184 [54-513]
- Not significantly different, substantial inter-individual variation
Renin vs vasoactive-inotropic score
- Plasma renin increase per unit increase in vasoactive-inotropic score (mIU L-1)
- 11
Prediction by model using all renin measurements
- Haemodynamic instability, AUC 0.77 [0.55-0.95]
- P = 0.04
- Shock, AUC 0.95 [0.83-1.0]
- P = < 0.001
Original publication
An Observational Study of Changes in Renin Concentrations and Associations With Complications Following Cardiac Surgery. Acta Anaesthesiol Scand. Published 5 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →