Analgesic efficacy and safety of methylene blue combined with cocktail for periarticular infiltration following total knee arthroplasty: a prospective, randomized, controlled study
Authors' conclusion
Methylene blue combined with a cocktail can be safely used for local infiltration after knee arthroplasty, which reduces postoperative opioid consumption and suppresses the release of inflammatory factors.
Study context
- Population
- Patients undergoing total knee arthroplasty under spinal anaesthesia, with IV PCA postoperatively
- Participants
- 70 patients
- Comparison
- M vs C
- Mn = 35
- Cn = 35reference
- Primary endpoint
- Rest and movement NRS scores
- Follow-up
- postoperative 24 h, 48 h, 72 h, 7-day, 14-day, 28-day
Methodological detailsprospective
- Prospective
Primary result
As reported in the abstract
postoperative 24 h, 48 h, 72 h, 7-day, 14-day, and 28-day
- Numeric Rating Scale (NRS) scores at rest and during movement significantly lower in the C group compared with the M group at all time points (P < 0.05), as printed
Further findings
Total sufentanil consumption · postoperative 72 h · less in the M group
P < 0.01
| Outcome | P value |
|---|---|
| IL-6 · postoperative 24 h and 72 hLower in the M group | P < 0.05 |
| CRP levels · 24 h and 72 h post-surgeryNo significant differences | P > 0.05 |
Safety
- Neither group experienced complications such as wound infection or poor wound healing
Original publication
Analgesic efficacy and safety of methylene blue combined with cocktail for periarticular infiltration following total knee arthroplasty: a prospective, randomized, controlled study. Perioper Med (Lond). Published 20 January 2025. doi:10.
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