Cardiothoracic & vascular anesthesia
Analgesic efficacy of the subtransverse process interligamentary plane block in thoracic surgery: A randomized, controlled, non-inferiority trial
Primary result · 48-h postoperative pain AUC during deep inspiration (per-protocol)Result — go to the resultMean difference 8.59 95% CI −0.94 to 18.14Authors' conclusion
This randomized clinical trial demonstrates that, in the studied population, the subtransverse process interligamentary plane block was non-inferior to the thoracic paravertebral block for postoperative pain control after thoracic surgery
Study context
- Population
- Patients undergoing video-assisted thoracoscopic surgery at a large academic medical center in China105 per-protocol
- Participants
- 114 patients
- Comparison
- STIL block vs thoracic paravertebral block (TPVB)
- STILn = 57
- TPVBn = 57reference
- Primary endpoint
- Pain intensity during deep inspiration (AUC of NRS)
- Follow-up
- 48 h postoperatively
Methodological detailsnon-inferiority, single-centre
- Non-inferiority
- Single-centre
Primary result
As reported in the abstract
48-h postoperative pain AUC during deep inspiration (per-protocol) · 48 h
Mean difference
8.59
95% CI −0.94 to 18.14
By group
STIL
196.04
± 2.50
TPVB
187.49
± 4.13
STIL vs TPVB
mean difference 8.59 (95% CI −0.94 to 18.14)
Non-inferiority margin 34 as printed, not drawn
Further findings
| Outcome | STIL | TPVB | Mean difference (95% CI) | |
|---|---|---|---|---|
| 48-h postoperative pain AUC during deep inspiration (intention-to-treat)Within the predefined noninferiority margin · intention-to-treat | 195.24 ± 2.49 | 186.44 ± 4.03 | 9.12 (−0.39 to 18.63) | |
| −1001020Difference (linear scale) |
Safety
Events
| Outcome | STIL | TPVB |
|---|---|---|
| Serious adverse events | 0 | 0 |
Original publication
Analgesic efficacy of the subtransverse process interligamentary plane block in thoracic surgery: A randomized, controlled, non-inferiority trial. J Clin Anesth. Published 15 February 2026. doi:10.
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