Perioperative medicine & outcomes
Analysis of inappropriate prophylactic use of proton pump inhibitors during the perioperative period: an observational study
Authors' conclusion
The inappropriate prophylactic use of PPIs during the perioperative period is common.
Study context
- Population
- Inpatients who underwent surgery and received prophylactic proton pump inhibitors (PPIs), tertiary care academic teaching hospital in China, June–November 2022
- Participants
- 472 inpatients
- Outcome
- Prevalence of inappropriate perioperative prophylactic use of PPIs (evaluated by clinical pharmacists)
Methodological detailssingle-centre, tertiary care academic teaching hospital
- Single-centre
- Tertiary care academic teaching hospital
Main finding
As reported in the abstract
At least one problem with inappropriate perioperative prophylactic PPI use
Patients with ≥1 inappropriate-use problem
131
27.75%
Drug use without indication
52.0%
Inappropriate usage and dosage
34.6%
Inappropriate duration of medication
6.7%
Observational data: associations, not effects.
Further findings
Factors associated with inappropriate prophylactic PPI use (multivariable logistic regression)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Oral dosage form of PPIsMore inappropriate use | 18.301 (7.497–44.671) | P < 0.001 | |
| Discharge medication of PPIsMore inappropriate use | 11.739 (1.289–106.886) | P = 0.029 | |
| Junior doctorsMore inappropriate use | 9.167 (3.459–24.299) | P < 0.001 | |
| AntithromboticsLess inappropriate use | 0.313 (0.136–0.721) | P = 0.006 | |
| Postoperative hospital stay >15 daysLess inappropriate use | 0.262 (0.072–0.951) | P = 0.042 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Analysis of inappropriate prophylactic use of proton pump inhibitors during the perioperative period: an observational study. Perioper Med (Lond). Published 14 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →