Cardiothoracic & vascular anesthesia
Analysis of Perioperative Factors Leading to Postoperative Pulmonary Complications, Graft Injury and Increased Postoperative Mortality in Lung Transplantation
Authors' conclusion
Clinical management and risk stratification focusing on the underlying identified factors that could help to improve patient outcomes.
Study context
- Population
- Patients undergoing lung transplantation, University Hospital, Medical Center Freiburg
- Participants
- 173 patients
- Outcome
- Perioperative risk factors for in-hospital mortality and postoperative complications (focus on PPCs and graft injury)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
In-hospital mortality (stepwise multivariate regression)
Odds ratio (95% CI)
Donor age >60 years
1.85(1.27–2.81)
Intraoperative ECMO
2.4(1.7–3.3)
Transfusion of >4 RBC concentrates
3.1(1.82–5.1)
Mean pulmonary artery pressure >30 mmHg at end of surgery
3.5(2–6.3)
Postoperative graft injury
4.1(2.8–5.9)
PPCs
2.1(1.7–2.6)
Sepsis
4.5(2.8–7.3)
Kidney disease Improving Outcome grading system stage 3 acute renal failure
4.3(2.4–7.7)
COPDreported as lower in-hospital mortality
1.6(1.4–1.9)
Observational data: associations, not effects.
Further findings
- Frequency and number of postoperative pulmonary complications (PPCs) correlated with postoperative mortality
Original publication
Analysis of Perioperative Factors Leading to Postoperative Pulmonary Complications, Graft Injury and Increased Postoperative Mortality in Lung Transplantation. J Cardiothorac Vasc Anesth. Published 8 August 2024. doi:10.
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