Cardiothoracic & vascular anesthesia
Prediction of Postoperative Lung Graft Dysfunction During the Procedure: A Single-Center Cohort Study of Cystic Fibrosis Patients
Authors' conclusion
This predictive model underscores the adverse impact of sustained ECMO placed at the end of surgery and elevated intraoperative lactate levels on PGD3 risk.
Study context
- Population
- Adult cystic fibrosis (CF) patients undergoing double-lung transplantation, 2012–2019, University Hospital, France (excluding multiorgan transplants, retransplantation, intraoperative CPB)
- Outcome
- PGD3 incidence and prediction model
- Follow-up
- POD 3
Methodological detailssingle-centre, Sixty-nine variables recorded in real time across nine predefined intraoperative time-points; logistic regression model
- Single-centre
- Sixty-nine variables recorded in real time across nine predefined intraoperative time-points; logistic regression model
Main finding
As reported in the abstract
Primary graft dysfunction (PGD3) occurred
24 patients
15.5%
Model AUC improved progressively during surgery
0.764 to 0.892
ECMO required at end of surgery: risk of PGD3 increased by a factor
11.48
95% CI 4.48–29.39p < 0.001
Each 1 mEq/L rise in lactate at time-point 7 (second pulmonary artery clamping): risk of PGD3 increased by
1.29
95% CI 1.02–1.63p = 0.035
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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