Cardiothoracic & vascular anesthesia
The Role of Recipient Thyroid Hormone Supplementation in Primary Graft Dysfunction After Heart Transplantation: A Propensity-Adjusted Analysis
Authors' conclusion
These findings indicated that recipient single-dose thyroid hormone administration may not protect against the development of PGD, but may attenuate the severity of PGD.
Study context
- Population
- Adult patients undergoing orthotopic heart transplantation, university hospital461 in final cohort
- Participants
- 609 patients
- Exposure
- Recipient T3 supplementation vs no T3
- Outcome
- PGD
Methodological detailssingle-centre, propensity-adjusted
- Single-centre
- Propensity-adjusted
Main finding
As reported in the abstract
P = 0.32
Observational data: associations, not effects.
Further findings
Mortality · 30 days
P = 0.53
Mortality · 1 year
P = 0.26
Moderate and severe primary graft dysfunction (PGD)
- No differences in rates of moderate or severe PGD
Severe PGD (segmented time regression analysis)
- T3 group less likely to develop severe PGD
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The Role of Recipient Thyroid Hormone Supplementation in Primary Graft Dysfunction After Heart Transplantation: A Propensity-Adjusted Analysis. J Cardiothorac Vasc Anesth. Published 23 July 2023. doi:10.
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