Cardiothoracic & vascular anesthesia
Perioperative Outcomes During Double-Lung Transplantation and Retransplantation in Cystic Fibrosis Patients: A Monocentric Cohort Study
Authors' conclusion
Intraoperative period of retransplantation was more convoluted but had a similar ECMO profile to primary transplantation. In addition, the early postoperative period was similar.
Study context
- Population
- Cystic fibrosis (CF) patients with primary double-lung transplantation or retransplantation, 2012–2021, Foch University Hospital, France
- Participants
- 258 vs 24
- Exposure
- Retransplantation vs primary double-lung transplantation
- pLgTxn = 258reference
- reLgTxn = 24
- Outcome
- Main intraoperative and early postoperative features
Methodological detailsmonocentric
- Monocentric
Main finding
As reported in the abstract
- reLgTx vs pLgTx: P = 0.02
- reLgTx vs pLgTx: P = 0.001
- reLgTx vs pLgTx: P = 0.009
- reLgTx vs pLgTx: P = 0.002
- reLgTx vs pLgTx: P = 0.001
Observational data: associations, not effects.
Further findings
Events
| Outcome | pLgTx | reLgTx | P value |
|---|---|---|---|
| Preoperative ECMO bridge | 23 | 0 | P = 0.24 |
| Intraoperative ECMO | 94 | 12 | P = 0.39 |
| ECMO not weaned after surgery | 55 | 4 | P = 0.54 |
| RRT in ICU | P = 0.08 | ||
| Mortality3 times higher in reLgTx; not statistically different | P = 0.17 |
- RRT in ICU: no difference despite worse preoperative renal function in reLgTx (p < 0.001)
Safety
Main complications, including primary graft dysfunction
- No differences between groups
Original publication
Perioperative Outcomes During Double-Lung Transplantation and Retransplantation in Cystic Fibrosis Patients: A Monocentric Cohort Study. J Cardiothorac Vasc Anesth. Published 23 February 2023. doi:10.
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