Analysis of Protein Biomarkers From Hospitalized COVID-19 Patients Reveals Severity-Specific Signatures and Two Distinct Latent Profiles With Differential Responses to Corticosteroids*
Authors' conclusion
In this multicenter study combining EHR data with research biomarker analysis of patients with COVID-19, we identified novel profiles with divergent clinical outcomes and differential treatment responses.
Study context
- Population
- Adults with COVID-19 presenting for acute care to EDs of four medical centres; inpatients analysedderivation, 3 sites
- Participants
- 522 adults
- Exposure
- Profile 2 vs profile 1
- Profile 2n = 190
- Profile 1n = 332reference
- Outcome
- In-hospital mortality
Methodological detailslatent profile analysis, external validation cohort, propensity matching, multicentre
- Latent profile analysis
- External validation cohort
- Propensity matching
- Multicentre
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
LOS
P < 0.001
| Outcome | OR |
|---|---|
| Glucocorticoid treatment and mortality (HTE by profile)Profile 1; increased mortality | 4.54 |
- Glucocorticoid treatment and mortality (HTE by profile): HTE p = 0.03
Validation cohort (single site, n = 192)
- Similar outcome differences between profiles
Biomarker levels by illness severity
- Biomarker levels generally paralleled illness severity, higher in more severely ill
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Analysis of Protein Biomarkers From Hospitalized COVID-19 Patients Reveals Severity-Specific Signatures and Two Distinct Latent Profiles With Differential Responses to Corticosteroids*. Crit Care Med. Published 28 June 2023. doi:10.
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