Plasma Metabolomics Reveals Distinct Biological and Diagnostic Signatures for Melioidosis
Authors' conclusion
Melioidosis induces a distinct metabolomic state that can be examined to distinguish underlying pathophysiological mechanisms associated with death. A 12-metabolite signature accurately differentiates melioidosis from other infections and may have diagnostic applications.
Study context
- Population
- Patients hospitalized with infection in rural Thailand
- Participants
- 175 vs 75
- Exposure
- Melioidosis vs nonmelioidosis infections; nonsurvivors vs survivors
- Melioidosisn = 175
- Nonmelioidosis infectionsn = 75reference
- Outcome
- Metabolomic profile and diagnostic classifier for melioidosis
Methodological detailsplasma metabolomics analysis, validation set
- Plasma metabolomics analysis
- Validation set
Main finding
As reported in the abstract
12-metabolite classifier distinguishing melioidosis from other infections, AUC in a second validation set
0.87
Observational data: associations, not effects.
Further findings
- Significantly disturbed metabolome in nonsurvivors vs survivors, with increased leucine, isoleucine and valine metabolism and elevated circulating free fatty acids and acylcarnitines
- A limited eight-metabolite panel showed promise as an early prognosticator of mortality in melioidosis
- Nonsurvivors n = 94; survivors n = 81
Original publication
Plasma Metabolomics Reveals Distinct Biological and Diagnostic Signatures for Melioidosis. Am J Respir Crit Care Med. Published 1 February 2024. doi:10.
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