Analysis of urinary C–C motif chemokine ligand 14 (CCL14) and first-generation urinary biomarkers for predicting renal recovery from acute kidney injury: a prospective exploratory study
Authors' conclusion
Urinary CCL14 and [TIMP-2] × [IGFBP7] were fair predictors of renal non-recovery from AKI.
Study context
- Population
- Intensive care unit (ICU) patients who developed acute kidney injury (AKI) after ICU admission64 (39.0%) non-recovery
- Participants
- 164 patients
- Comparison
- CCL14 vs [TIMP-2] × [IGFBP7] vs neutrophil gelatinase-associated lipocalin (NGAL)
- Outcome
- Non-recovery from AKI
- Follow-up
- Within 7 days
Methodological detailsprospective, exploratory
- Prospective
- Exploratory
Performance
As reported in the abstract
Prediction of renal non-recovery
| Test or model | AUC |
|---|---|
| CCL14 | 0.71 (95% CI 0.63-0.77, p < 0.001) |
| [TIMP-2] × [IGFBP7] | 0.78 (95% CI 0.71-0.84, p < 0.001) |
| NGAL | 0.53 (95% CI 0.45-0.60, p = 0.562) |
AUC
CCL140.71 (95% CI 0.63-0.77, p < 0.001)
[TIMP-2] × [IGFBP7]0.78 (95% CI 0.71-0.84, p < 0.001)
NGAL0.53 (95% CI 0.45-0.60, p = 0.562)
Further findings
Clinical model (non-renal SOFA score and AKI stage)
- AUC
- 0.77 (95% CI 0.77-0.83, p = 0.004)
[TIMP-2] × [IGFBP7] combined with clinical model
- AUC significantly improved
- 0.82 (95% CI 0.74-0.87, p = 0.049)
Original publication
Analysis of urinary C–C motif chemokine ligand 14 (CCL14) and first-generation urinary biomarkers for predicting renal recovery from acute kidney injury: a prospective exploratory study. J Intensive Care. Published 20 March 2023. doi:10.
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