Application of urinary biomarkers for diagnosing acute kidney injury in critically ill patients without baseline renal function data
Authors' conclusion
The novel diagnostic rule incorporating serum creatinine and urinary NGAL at ICU admission showed superiority to the MDRD approach in AKI diagnosis without baseline renal function data.
Study context
- Population
- Adult intensive care unit (ICU) patients without premorbid baseline renal function data
- Participants
- 243 patients
- Exposure
- Decision rule vs Modification of Diet in Renal Disease (MDRD)-based imputation of baseline
- Outcome
- Misclassification rate of acute kidney injury (AKI) diagnosis
Methodological detailssingle ICU, classification and regression tree (CART) analysis, development and validation cohorts
- Single ICU
- Classification and regression tree (CART) analysis
- Development and validation cohorts
Main finding
As reported in the abstract
Misclassification rate (validation cohort)
P = 0.002
Observational data: associations, not effects.
Further findings
Net benefit (decision curve analysis)
- Net benefit of decision rule exceeded MDRD approach at threshold probability of 25% and higher
Original publication
Application of urinary biomarkers for diagnosing acute kidney injury in critically ill patients without baseline renal function data. J Crit Care. Published 12 April 2023. doi:10.
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