Hemodynamics, fluids & transfusion
Anemia of Critical Illness: A Concise Definitive Review in Critical Care
Study context
- Population
- ICU patients with anemia of critical illness
Methodological detailsconcise definitive review, Sources: PubMed and MEDLINE; preclinical studies, clinical trials and observational studies on diagnosis, pathophysiology and treatment
- Concise definitive review
- Sources: PubMed and MEDLINE; preclinical studies, clinical trials and observational studies on diagnosis, pathophysiology and treatment
Main finding
As reported in the abstract
- Anemia of critical illness is highly prevalent, persists after ICU discharge and is associated with adverse outcomes
- Most ICU patients have anemia of inflammation (high hepcidin, low erythropoietin, low erythroferrone, iron-restricted erythropoiesis) or iron deficiency anemia (low hepcidin)
- Nontransferrin bound (catalytic) iron catalyzes reactive oxygen species and is associated with organ failure in ICU patients
- PBM (early diagnosis, diagnosis-specific treatment, optimizing hemostasis, blood conservation incl. phlebotomy reduction) can result in improved outcomes in the critically ill
Original publication
Anemia of Critical Illness: A Concise Definitive Review in Critical Care. Crit Care Med. Published 25 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →