Pediatric anesthesia & critical care
Anesthesia management protocol for liver transplantation as treatment for ornithine transcarbamylase deficiency
Authors' conclusion
Liver transplantation for cases with uncontrolled hyperammonemia can be performed with proper management. Second, liver transplantation with carrier donors should be avoided because of the risk of postoperative recurrence.
Study context
- Population
- Liver transplantation cases for ornithine transcarbamylase deficiency, November 2005–March 2021
- Participants
- 29 liver transplantation cases
- Outcome
- Perioperative course
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Stable through the perioperative period
25
Hyperammonemia after liver transplantation, carrier donor graft
2
Uncontrolled hyperammonemia before liver transplantation despite continuous hemodialysis; life-saving transplantation, metabolic status stabilised after anhepatic phase
2
Observational data: associations, not effects.
Original publication
Anesthesia management protocol for liver transplantation as treatment for ornithine transcarbamylase deficiency. Paediatr Anaesth. Published 4 May 2023. doi:10.
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