Antimicrobial Exposures in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation
Authors' conclusion
Antimicrobial PKs were highly variable in critically ill patients receiving ECMO, leading to poor target attainment rates.
Study context
- Population
- Critically ill adults receiving Extracorporeal Membrane Oxygenation (ECMO) in six ICUs in Australia, New Zealand, South Korea and Switzerland993 blood samples
- Participants
- 85 adults
- Outcome
- Pharmacokinetics of antimicrobials (11 antimicrobials) during ECMO
- Follow-up
- Single dosing interval
Methodological detailsopen-labeled, multicentre (six ICUs)
- Open-labeled
- Multicentre (six ICUs)
Main finding
As reported in the abstract
Antimicrobial pharmacokinetics (PKs)
- Large variations in antimicrobial concentrations (coefficient of variation ⩾30%), >fivefold variations in all PK parameters across all study antimicrobials
Observational data: associations, not effects.
Further findings
Target concentration and exposure range attainment (overall)
- Concentration profiles achieving predefined target
- 70 (56.5%)
- Not significantly different between ECMO modes and RRT
Target attainment by antimicrobial
- Oseltamivir
- 33.3%
- Piperacillin
- 44.4%
- Vancomycin
- 27.3%
Original publication
Antimicrobial Exposures in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation. Am J Respir Crit Care Med. Published 15 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →