Apolipoprotein A1 (ApoA1)/high-density lipoprotein (HDL) and sepsis-associated vascular endothelial injury: a narrative review
Authors' conclusion
By providing an integrated mechanistic framework, this review highlights the ApoA1 as a critical therapeutic target
Study context
- Population
- Sepsis-associated vascular endothelial injury
Main finding
As reported in the abstract
- Strong correlation between reduced ApoA1/HDL levels and endothelial damage across various infections
- Protective mechanisms: anti-inflammatory actions, preservation of endothelial barrier integrity, restoration of microvascular flow
- Emerging interplay between ApoA1 and exosomes
- Translational potential of ApoA1-based therapies (mimetic peptides, recombinant HDL) evaluated
Original publication
ApoA1/HDL and sepsis-associated vascular endothelial injury: a narrative review. Crit Care. Published 8 October 2025. doi:10.
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