Cardiothoracic & vascular anesthesia
Application of Alfentanil Combined With Dexmedetomidine for Conscious Sedation of Patients During Transesophageal Echocardiography Examination
Authors' conclusion
Intravenous alfentanil combined with dexmedetomidine effectively inhibits pharyngeal reflexes and demonstrates a favorable safety profile, with fewer incidents of hypotension but a higher incidence of manageable respiratory depression compared with the MD protocol.
Study context
- Population
- Outpatients undergoing transesophageal echocardiography (TEE) under conscious sedation, university-affiliated teaching hospital
- Participants
- 80 outpatients
- Comparison
- Alfentanil + dexmedetomidine (AD) vs MD
- ADn = 40
- MDn = 40reference
- Primary endpoint
- Initial sedation success rate (pharyngeal reflex grade <3, no excessive sedation [Ramsay sedation score >4], no serious adverse effects)
Methodological detailsprospective, double-blind
- Prospective
- Double-blind
Primary result
As reported in the abstract
P < 0.001
Further findings
| Outcome | AD | MD | P value |
|---|---|---|---|
| Recovery timeSignificantly shorter in AD | 626.25 ± 295.80 | 768.33 ± 310.43 | P < 0.05 |
Safety
Hypotension
P < 0.05
Respiratory depression
P < 0.01
Respiratory depression
- No hypoxia and asphyxia in either group
Serious complications
- No serious complications in either group
Original publication
Application of Alfentanil Combined With Dexmedetomidine for Conscious Sedation of Patients During Transesophageal Echocardiography Examination. J Cardiothorac Vasc Anesth. Published 30 January 2025. doi:10.
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