Respiratory failure & ventilation
Approaches to Mechanical Ventilation in Patients With and Without Acute Brain Injury: A Registry-Based Cohort Study
Authors' conclusion
Both ABI and non-ABI patients received comparable V t that trended downwards over time. Pa co2 and Pa o2 remained largely within guideline-recommended ranges. However, PEEP was significantly lower in ABI patients, including among those with hypoxemic respiratory failure
Study context
- Population
- Adults (≥ 18 yr) receiving invasive ventilation for at least 48 hours, nine ICUs in Toronto, Canada, 2014 to 202325.2% acute brain injury (ABI)
- Participants
- Thirteen thousand nine hundred twenty-five adults
- Exposure
- ABI vs non-ABI
- ABIn = 3,503
- Outcome
- Ventilation settings
- Follow-up
- First 7 ventilation days
Methodological detailsprospectively collected data, multicentre (nine ICUs), adjusted linear mixed-effects regression
- Prospectively collected data
- Multicentre (nine ICUs)
- Adjusted linear mixed-effects regression
Main finding
As reported in the abstract
P < 0.001
- Tidal volume comparable between groups, daily median close to 6 mL/kg predicted body weight (IQR 6-7 mL/kg)
- 6
Observational data: associations, not effects.
Further findings
Positive end-expiratory pressure (PEEP) in hypoxemic respiratory failure (subgroup)
- PEEP remained significantly lower in the ABI subset
Trends 2014 to 2023
- Tidal volume decreased slightly in both groups; PEEP unchanged
PaCO2 and PaO2 in ABI
- PaCO2 largely maintained within 35-45 mm Hg
- PaO2 largely within 80-120 mm Hg
Six additional ventilation parameters
- Minimal differences between groups
- Unadjusted analyses
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →