Neuroanesthesia & neurocritical care
Timing of Extubation in Adult Patients with Acute Brain Injury
Main finding · Ventilator-free days up to 28 daysResult — go to the resultIncidence rate ratio 1.24 95% CI 1.19–1.29Authors' conclusion
Prompt extubation after a first successful spontaneous breathing trial was associated with more ventilator-free days (up to 28 d) among adults with acute brain injury receiving invasive mechanical ventilation.
Study context
- Population
- Mechanically ventilated adults with acute brain injury with a first successful SBT, 8 ICUs in Toronto, Canada, April 2014–March 202357% prompt extubation
- Participants
- 1,406 participants
- Exposure
- Prompt extubation vs no prompt extubation after a first successful SBT
- Outcome
- Ventilator-free days
- Follow-up
- Up to 28 days
Methodological detailsemulation of a previously designed randomised controlled trial, inverse probability of treatment weighting, multicentre registry
- Emulation of a previously designed randomised controlled trial
- Inverse probability of treatment weighting
- Multicentre registry
Main finding
Ventilator-free days up to 28 days
Incidence rate ratio
1.24
95% CI 1.19–1.29
Prompt extubation vs No prompt extubation
IRR 1.24 (95% CI 1.19–1.29)
As reported in the abstract
Observational data: associations, not effects.
Original publication
Timing of Extubation in Adult Patients with Acute Brain Injury. Am J Respir Crit Care Med. Published 1 March 2025. doi:10.
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