Neuroanesthesia & neurocritical care
Spontaneous breathing trials as predictors of extubation outcomes in neurocritical care: insights from the ENIO study
Authors' conclusion
In this large international ABI cohort, neither SBT mode nor duration was associated with extubation failure.
Study context
- Population
- Mechanically ventilated patients with acute brain injury (ABI) with available spontaneous breathing trial (SBT) data, undergoing extubation attemptof 1,512 enrolled in ENIO
- Participants
- 839 participants
- Comparison
- SBT with pressure support ventilation (PSV) vs T-piece vs continuous positive airway pressure (CPAP)
- PSVn = 430
- T-piecen = 329
- CPAPn = 80
- Primary endpoint
- Extubation failure
- Follow-up
- Within 5 days
Methodological detailspost-hoc analysis, multivariable logistic regression, inverse probability of treatment weighting
- Post-hoc analysis
- Multivariable logistic regression
- Inverse probability of treatment weighting
Primary result
As reported in the abstract
Extubation failure, all patients
177
21.1%
Further findings
SBT median duration
ABI subgroups (subgroup)
- Results similar in ABI subgroup analyses
Predictors of extubation success after inverse probability weighting
- Vigorous cough the only significant predictor of extubation success
Original publication
Spontaneous breathing trials as predictors of extubation outcomes in neurocritical care: insights from the ENIO study. Intensive Care Med. Published 13 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →