Neuroanesthesia & neurocritical care
Evaluating the Sum of Eye and Motor Components of the Glasgow Coma Score As a Predictor of Extubation Failure in Patients With Acute Brain Injury
Primary result · Extubation failureResult — go to the resultOdds ratio 1.07 95% CI 0.87–1.31Authors' conclusion
In this large, contemporary, multicenter cohort of patients with acute brain injury, we found no association between the GCS-EM and odds of extubation failure.
Study context
- Population
- Critically ill patients with acute brain injury being liberated from mechanical ventilation, 63 hospital sites worldwide, January 2018 to November 2020
- Participants
- 1,152 patients · 63 sites
- Comparison
- Pre-extubation GCS-EM per additional point
- Primary endpoint
- Extubation failure (unplanned reintubation within 5 days of extubation)
- Follow-up
- 5 days
Methodological detailsmultilevel logistic regression
- Multilevel logistic regression
Primary result
Extubation failure
Odds ratio
1.07
95% CI 0.87–1.31
GCS-EM per additional point
OR 1.07 (95% CI 0.87–1.31)
Per additional point, as printed
As reported in the abstract
Further findings
Sensitivity analyses (different covariates, overall GCS, missing data, 2-day interval, competing risks, propensity score model)
- Findings consistent
Subgroups by brain injury diagnosis or age (subgroup)
- No association between GCS-EM and extubation outcome
Original publication
Evaluating the Sum of Eye and Motor Components of the Glasgow Coma Score As a Predictor of Extubation Failure in Patients With Acute Brain Injury. Crit Care Med. Published 1 April 2024. doi:10.
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