Neuroanaesthesia & neurocritical care
Low-Tidal-Volume Ventilation and Mortality in Patients With Acute Brain Injury: A Secondary Analysis of an International Observational Study
Primary result · ICU mortality (adjusted incidence)Result — go to the resultMarginal HR 0.54 95% CI 0.33–0.88Authors' conclusion
In this predominantly non-ARDS cohort of patients with ABI, LTVV over the first 7 days of mechanical ventilation was associated with lower ICU mortality up to 60 days, vs tidal volumes > 8 mL/kg PBW.
Study context
- Population
- Mechanically ventilated patients with acute brain injury (ABI), predominantly non-ARDS; 73 ICUs across 18 countries
- Participants
- 1,510 participants · 73 ICUs · 18 countries
- Comparison
- Low-tidal-volume ventilation (LTVV) vs > 8 mL/kg PBW
- Primary endpoint
- ICU mortality
- Follow-up
- Up to 60 days
Methodological detailsmarginal structural Cox models, stabilized inverse probability treatment and censoring weights, multicentre
- Marginal structural Cox models
- Stabilized inverse probability treatment and censoring weights
- Multicentre
Primary result
ICU mortality (adjusted incidence)
Marginal HR
0.54
95% CI 0.33–0.88
By group
LTVV vs > 8 mL/kg PBW
marginal HR 0.54 (95% CI 0.33–0.88)
As reported in the abstract
Further findings
Subgroup analyses (subgroup)
- No heterogeneity of treatment effect
Sensitivity analyses for unmeasured confounding
- Similar results
Lower LTVV thresholds (alternate analyses)
- Associations less clear
Original publication
Low-Tidal-Volume Ventilation and Mortality in Patients With Acute Brain Injury: A Secondary Analysis of an International Observational Study. Chest. Published 8 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →