Neuroanesthesia & neurocritical care
Association of age with extubation failure in neurocritical intensive care unit patients––Insight from an international prospective study named ENIO
Authors' conclusion
In this international cohort of intubated and ventilated neurocritical care patients, after adjusting for baseline covariates and for previously identified risk factors for extubation failure, age was not associated with extubation failure.
Study context
- Population
- Neurocritical care patients with GCS ≤ 12 ventilated for at least 24 h; 73 centres in 18 countries, 2018–2020median age 53 [35 to 65] years
- Participants
- 1,095 patients
- Comparison
- Age and extubation failure
Methodological detailspost hoc analysis, international, multicentre
- Post hoc analysis
- International
- Multicentre
Primary result
As reported in the abstract
Extubation failure
Odds ratio (95 % CI)P value
Ageadjusted for confounding factors; no longer significant
1.008(0.997–1.019)
P = 0.172Older patientsunadjusted analysis
1.012(1.004–1.021)
P = 0.006- Extubation failure, all patients
- 209 (19 %)
Further findings
Admission diagnosis by age
- Younger patients more often TBI; older patients more often cerebral hemorrhage, ischemic stroke, central nervous infection or brain malignancies
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of age with extubation failure in neurocritical intensive care unit patients––Insight from an international prospective study named ENIO. J Crit Care. Published 3 April 2025. doi:10.
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