Area under the curve and amplitude of the compound motor action potential are clinically interchangeable quantitative measures of neuromuscular block: a method comparison study
Authors' conclusion
Quantitative assessment neuromuscular block depth is clinically interchangeable when calculated using cMAP amplitude or the AUC.
Study context
- Population
- Patients given rocuronium in two published studies, digitised electromyography (EMG) waveforms
- Participants
- 48 participants
- Comparison
- Amplitude vs AUC
- Primary endpoint
- Agreement of T1/T1c and TOFR between amplitude and AUC (proportion of paired differences outside prespecified clinical limits of agreement)
Methodological detailsrepeated measures Bland-Altman analysis, secondary analysis of two published studies
- Repeated measures Bland-Altman analysis
- Secondary analysis of two published studies
Primary result
As reported in the abstract
Paired differences outside prespecified clinical limits of agreement
T1/T1c ≤0.2 (2419 pairs): outside limits (−0.148 to 0.164)
8
0.33%
TOFR ≥0.8 (1781 pairs): outside limits (−0.109 to 0.134)
70
3.93%
Further findings
Mean bias, all paired T1/T1c differences
- Mean bias (7286 paired differences)
- 0.32 (95% CI 0.202-0.043)
- Repeated measures Bland-Altman analysis
Mean bias, all paired TOFR differences
- Mean bias (5559 paired differences)
- 0.011 (95% CI 0.0050-0.017)
- Repeated measures Bland-Altman analysis
Lin's concordance correlation coefficient
- T1/T1c
- 0.98
- TOFR
- 0.995
Repeatability coefficients for T1/T1c and TOFR
- Repeatability coefficients for T1/T1c and TOFR
- <0.08
- No differences between methods
Original publication
Area under the curve and amplitude of the compound motor action potential are clinically interchangeable quantitative measures of neuromuscular block: a method comparison study. BJA Open. Published 13 June 2024. doi:10.
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