Aspirin is associated with improved outcomes in patients with sepsis-induced myocardial injury: An analysis of the MIMIC-IV database
Main findingResult — go to the resultHazard ratio 0.51 95 % CI 0.42–0.63Authors' conclusion
Aspirin was associated with decreased mortality in SIMI patients, and this beneficial effect persisted regardless of pre-ICU treatment.
Study context
- Population
- Patients with sepsis-induced myocardial injury (SIMI) in the MIMIC-IV database1,055 after PSM
- Participants
- 1,170 patients
- Exposure
- Aspirin vs no aspirin during intensive care unit (ICU) stay
- Outcome
- All-cause mortality
- Follow-up
- 28 days
Methodological detailspropensity-score matched, MIMIC-IV database
- Propensity-score matched
- MIMIC-IV database
Main finding
As reported in the abstract
Hazard ratio
0.51
95 % CI 0.42–0.63
P < 0.001
Aspirin vs Non-aspirin
HR 0.51 (95 % CI 0.42–0.63); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | HR (95 % CI) | P value | |
|---|---|---|---|
| 90-day mortality · propensity-matched cohort | 0.58 (0.49–0.69) | P < 0.001 | |
| 1-year mortalityPropensity-matched cohort | 0.65 (0.56–0.76) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
Sensitivity analysis, original cohort
- Confirmed the robustness of the findings
Subgroups (vasopressin use)
- Vasopressin use had a significant interaction with aspirin's efficacy
Original publication
Aspirin is associated with improved outcomes in patients with sepsis-induced myocardial injury: An analysis of the MIMIC-IV database. J Clin Anesth. Published 7 September 2024. doi:10.
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