Assessing the impact of a multidimensional approach and an 8-component bundle in reducing incidences of ventilator-associated pneumonia across 35 countries in Latin America, Asia, the Middle East, and Eastern Europe
Authors' conclusion
This intervention resulted in a significant VAP rate reduction by 66% that was maintained throughout the 39-month period.
Study context
- Population
- Patients in 374 intensive care unit (ICUs) across 35 low and middle-income countries (LMICs) from Latin-America, Asia, Eastern-Europe and the Middle-East
- Participants
- 174,987 patients · 374 ICUs · 35 LMICs
- Comparison
- Multidimensional approach and 8-component bundle: intervention periods vs baseline
- Outcome
- VAP rate per 1000 mechanical ventilator (MV)-days
Methodological detailsmulticentre, multidimensional approach, 8-component bundle, 1,201,592 patient-days; 463,592 mechanical ventilator (MV)-days
- Multicentre
- Multidimensional approach
- 8-component bundle
- 1,201,592 patient-days; 463,592 MV-days
Main finding
As reported in the abstract
VAP per 1000 MV-days
Each group vs baselineRelative risk (95% CI)P value
2nd month
0.61(0.58–0.65)
P < 0.0013rd month
0.49(0.46–0.52)
P < 0.0014-15 month
0.51(0.48–0.53)
P < 0.00116-27 month
0.41(0.38–0.42)
P < 0.00128-39 month
0.34(0.32–0.36)
P < 0.001Further findings
| Outcome | IRR | P value |
|---|---|---|
| VAP incidence, multilevel Poisson regression · 28th to 39th months28-39 month vs Baseline | 0.39 | P < 0.0001 |
Ventilator associated pneumonia (VAP) incidence, multilevel Poisson regression · 28th to 39th months
- Continuous significant decrease in IRR
Original publication
Assessing the impact of a multidimensional approach and an 8-component bundle in reducing incidences of ventilator-associated pneumonia across 35 countries in Latin America, Asia, the Middle East, and Eastern Europe. J Crit Care. Published 20 December 2023. doi:10.
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