Pediatric anesthesia & critical care
Assessment of fluid responsiveness in children using respiratory variations in descending aortic flow
Authors' conclusion
In mechanically ventilated children, ΔVpeak dAo identified fluid responders with moderate diagnostic power in the current study. ΔVpeak LVOT failed to predict fluid responders in the current study.
Study context
- Population
- Anesthetized mechanically ventilated children (mean age 43 months, weight 16 kg); responders = stroke volume index increase >15% after 10 mL kg-1 fluid bolus12 responders · 15 non-responders
- Participants
- 27 participants
- Comparison
- ΔVpeak dAo vs ΔVpeak LVOT for predicting fluid responsiveness
- Outcome
- Ability of ΔVpeak dAo to predict fluid responsiveness (ROC analysis)
Methodological detailsprospective observational
- Prospective observational
Performance
As reported in the abstract
Prediction of fluid responsiveness
| Test or model | AUC | Sensitivity (>14%) | Specificity (>14%) |
|---|---|---|---|
| ΔVpeak dAo | 0.73 (95% CI: 0.52-0.89, p = .02) | 58% (95% CI: 28%-85%) | 73% (95% CI: 45%-92%) |
| ΔVpeak LVOT | 0.56 (0.34-0.78, p = .3) | — not stated in the abstract | — not stated in the abstract |
AUC
ΔVpeak dAo0.73 (95% CI: 0.52-0.89, p = .02)
ΔVpeak LVOT0.56 (0.34-0.78, p = .3)
Sensitivity (>14%)
ΔVpeak dAo58% (95% CI: 28%-85%)
ΔVpeak LVOT— not stated in the abstract
Specificity (>14%)
ΔVpeak dAo73% (95% CI: 45%-92%)
ΔVpeak LVOT— not stated in the abstract
— not stated in the abstract
Further findings
| Outcome | Responders | Non-responders | P value |
|---|---|---|---|
| Baseline ΔVpeak dAo, responders vs non-responders | 14% (95% CI 12%–17%) | 11% (95% CI 9%–13%) | P = 0.04 |
Original publication
Assessment of fluid responsiveness in children using respiratory variations in descending aortic flow. Acta Anaesthesiol Scand. Published 11 May 2023. doi:10.
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