Assessment of Gastric Content Using Gastric Ultrasound in Patients on Glucagon-Like Peptide-1 Receptor Agonists Before Anesthesia
Authors' conclusion
In preoperatively fasting adults, ≤7.5 days of withholding injections and ≤21.3 hours of fasting from solid food are associated with high RGC.
Study context
- Population
- Adults taking GLP-1 RAs scheduled for anesthesia at 3 hospitals, June 30, 2023–August 15, 2024
- Participants
- 316 adults
- Exposure
- High vs low residual gastric content on preoperative gastric ultrasonography (GUS)
- High residual gastric contents (RGC)n = 113
- Low RGCn = 203reference
- Outcome
- High RGC (solid food or >1.5 mL/kg clear liquids on GUS) and its association with preoperative factors
Methodological detailsmulticentre, point-of-care gastric ultrasonography
- Multicentre
- Point-of-care gastric ultrasonography
Main finding
As reported in the abstract
Prevalence of high RGC and associated preoperative factors
High RGC
35.8%
113
- Opioid prescription within 3 months of GUS: High RGC 5.3% (6/113) vs Low RGC 1.0% (2/203)
- P = 0.027
- Days withholding GLP-1 RA (weekly injections): Low RGC 8 days [5-10] vs High RGC 6 days [3-9]
- P = 0.003
- ROC cutoff for increased prevalence of high RGC: withholding injections
- ≤7.5 days
- Solid-food fasting: Low RGC 20.0 hours [14.8-40.8] vs High RGC 15.0 hours [12.8-19.0]
- P < 0.001
- ROC cutoff for increased prevalence of high RGC: solid-food fasting
- ≤21.3 hours
Observational data: associations, not effects.
Further findings
High RGC among patients on weekly injections
- High RGC among patients on weekly injections: 294 patients taking weekly injections
Original publication
Assessment of Gastric Content Using Gastric Ultrasound in Patients on Glucagon-Like Peptide-1 Receptor Agonists Before Anesthesia. Anesth Analg. Published 1 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →