Perioperative medicine & outcomes
Assessment of Perioperative Protamine Reactions in Patients With Fish Allergies: A Retrospective Observational Study
Authors' conclusion
The study findings suggest that in patients with a history of fish allergy, cross-reactivity with protamine is unlikely, as anaphylaxis and/or protamine reactions were rare in this patient population in the perioperative environment.
Study context
- Population
- Adults with documented fish allergy undergoing surgery involving protamine, large academic tertiary referral center, 2008–2018
- Participants
- 214 adults
- Outcome
- Incidence and severity of perioperative protamine reactions (anaphylaxis or protamine reaction)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Anaphylaxis or protamine reactions · perioperative
Anaphylaxis or protamine reaction cases among 214 patients
2
<1%
Observational data: associations, not effects.
Further findings
Cardiac procedures
- Cardiac procedures most common
- 67%
Intraoperative heparin dosage
- Median intraoperative heparin dosage
- 46,000 IU
Protamine dosage
- Median protamine dosage
- 310 mg
Postoperative ICU admission
- Admitted to ICU postoperatively
- 99%
Hospital stay
- Median hospital stay (IQR 5.2-14.6 days)
- 6.5 days
Deaths · 30 days
- Deaths within 30 days
- 3 (1%)
Deaths · 1 year
- Deaths within 1 year
- 15 (7%)
Original publication
Assessment of Perioperative Protamine Reactions in Patients With Fish Allergies: A Retrospective Observational Study. J Cardiothorac Vasc Anesth. Published 23 August 2024. doi:10.
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