Assessment of Racial, Ethnic, and Sex-Based Disparities in Time-to-Antibiotics and Sepsis Outcomes in a Large Multihospital Cohort*
Authors' conclusion
In a large cohort of patients with sepsis, time-to-antibiotics was longer for both women and Black patients even after detailed risk-adjustment. Women with septic shock had higher adjusted in-hospital mortality than men, but this association was not moderated by time-to-antibiotics.
Study context
- Population
- Adults admitted 2015–2022 with suspected sepsis or septic shock, five Massachusetts hospitals
- Exposure
- Women vs men; Black vs White patients
- Womenn = 22,598
- Blackn = 4,483
- Whiten = 36,626reference
- Outcome
- Time-to-antibiotics
Methodological detailsmultihospital
- Multihospital
Main finding
As reported in the abstract
Adjusted odds ratio (95% CI)
Women vs Mensepsis; 3-6 vs. < 3 hr
1.16(1.07–1.25)
Women vs Menseptic shock; 3-6 vs. < 3 hr
1.09(1.01–1.18)
Black vs Whitesepsis; 3-6 vs. < 3 hr
1.24(1.06–1.45)
Black vs Whiteseptic shock
1.32(1.12–1.55)
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| In-hospital mortality, septic shockWomen vs Men | 1.16 (1.04–1.29) | |
| In-hospital mortality, septic shockWomen vs Men · also adjusted for time-to-antibiotics | 1.16 (1.03–1.32) | |
| 0.512Adjusted odds ratio (log scale) |
In-hospital mortality, sepsis without shock
- No association between race/ethnicity/sex and in-hospital mortality
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Assessment of Racial, Ethnic, and Sex-Based Disparities in Time-to-Antibiotics and Sepsis Outcomes in a Large Multihospital Cohort*. Crit Care Med. Published 16 September 2024. doi:10.
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