ICU sedation, delirium & recovery
Association between ABCDE bundle compliance and long-term outcomes: a secondary longitudinal analysis
Authors' conclusion
In this multi-site cohort with high-fidelity bundle compliance, greater bundle compliance was associated with less disability in instrumental activities of daily living and better health-related quality of life at 12 months, though associations were inconsistent and absent across other domains.
Study context
- Population
- Adults with respiratory failure and/or shock in ICU, 16 US medical centres, 2011–2017251 assessed at 12 months
- Participants
- 566 adults
- Comparison
- Greater vs lesser proportional ABCDE bundle compliance
- Primary endpoint
- Cognition, disability, mental health, quality of life and survival
- Follow-up
- 3 and 12 months after hospital discharge
Methodological detailslongitudinal, multicentre
- Longitudinal
- Multicentre
Primary result
As reported in the abstract
Association of greater bundle compliance with long-term outcomes (adjusted) · 12 months
Functional Activity Questionnaire score (lower = better), β (CI - 19.6, - 1.7), p = 0.04
- 9.6
EuroQol-5D score, β (CI 0.1, 0.9), p = 0.01
0.5
Original publication
Association between ABCDE bundle compliance and long-term outcomes: a secondary longitudinal analysis. Intensive Care Med. Published 25 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →