ICU sedation, delirium & recovery
Post–Intensive Care Syndrome and Caregiver Burden: A Post Hoc Analysis of a Randomized Clinical Trial
Authors' conclusion
In this secondary analysis of a randomized clinical trial of ICU survivors and their caregivers, patient PICS and caregiver burden were associated at concurrent time points but were not associated with each other longitudinally.
Study context
- Population
- Adult intensive care units (ICU) survivors with ICU delirium and their unpaid caregivers, 16 US academic medical centers (2011–2017)
- Participants
- 148 patient-caregiver dyads
- Comparison
- Associations between patient post-intensive care syndrome (PICS) and caregiver burden at 3 and 12 months
- Primary endpoint
- Cross-lagged associations between 3-month PICS (physical, cognitive function, PTSD) and 12-month caregiver burden (Zarit Burden Interview), and vice versa
- Follow-up
- 3 and 12 months
Methodological detailsmulticentre, structural equation modeling
- Multicentre
- Structural equation modeling
Primary result
As reported in the abstract
Cross-lagged associations · 3 → 12 months
β
0.82
95% CI −0.02 to 1.66P = 0.09
3-month PICS → 12-month caregiver burden
β
0.00
95% CI −0.03 to 0.03P = 0.95
3-month caregiver burden → 12-month PICS
Further findings
| Outcome | β (95% CI) | P value |
|---|---|---|
| Stability of PICS, 3 → 12 months | 0.69 (0.50–0.88) | P < 0.001 |
| Stability of caregiver burden, 3 → 12 months | 0.68 (0.53–0.82) | P < 0.001 |
Concurrent covariance of PICS and caregiver burden · each time point
- Significant covariance between PICS and caregiver burden at each time point
Original publication
Post–Intensive Care Syndrome and Caregiver Burden: A Post Hoc Analysis of a Randomized Clinical Trial. JAMA Netw Open. Published 1 April 2025. doi:10.
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