Association between alactic base excess on mortality in sepsis patients: a retrospective observational study
Authors' conclusion
ABE demonstrated a U-shaped association with 30-day and 90-day ICU all-cause mortality in critically ill sepsis patients, suggesting its superiority over BE and lactate as a predictive biomarker.
Study context
- Population
- Intensive care unit (ICU) patients with sepsis, large US ICU sepsis cohort; Alactic base excess (ABE) = lactate + base excess (BE) on first ICU day
- Participants
- 17,099 patients
- Exposure
- ABE quartiles
- Outcome
- ICU all-cause mortality
- Follow-up
- 30-day/90-day
Methodological detailsobservational, quartile analysis, restricted cubic spline
- Observational
- Quartile analysis
- Restricted cubic spline
Main finding
As reported in the abstract
30-day ICU all-cause mortality · 30-day
Hazard ratio (95% CI)
Q1
1.27(1.13–1.44)
Q4
1.17(1.06–1.31)
Observational data: associations, not effects.
Further findings
90-day ICU all-cause mortality
| HR (95% CI) | ||
|---|---|---|
| Q1 | 1.28 (1.16–1.44) | |
| Q2 | 1.12 (1.02–1.23) | |
| Q4 | 1.22 (1.11–1.34) | |
| 0.512Hazard ratio (log scale) |
Predictive performance
- ABE superior to BE and lactate for predicting mortality
- Adding ABE to SOFA score improved predictive performance
Optimal ABE thresholds
mmol/L
- Threshold for 30-day mortality
- 2.5
- Threshold for 90-day mortality
- 2.2
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between alactic base excess on mortality in sepsis patients: a retrospective observational study. J Intensive Care. Published 11 April 2025. doi:10.
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