Cardiothoracic & vascular anaesthesia
The association between atherogenic index of plasma and postoperative delirium in cardiac surgery patients: an analysis of the MIMIC-IV database
Authors' conclusion
AIP was independently and nonlinearly associated with an increased risk of POD following cardiac surgery.
Study context
- Population
- Patients undergoing cardiac surgery, MIMIC-IV 2.2 database3,130 analysed after propensity score matching (PSM)
- Participants
- 6,067 patients
- Exposure
- Higher vs lower atherogenic index of plasma (AIP)
- Outcome
- POD
Methodological detailspropensity-score matched (1:1), MIMIC-IV 2.2 database
- Propensity-score matched (1:1)
- MIMIC-IV 2.2 database
Main finding
As reported in the abstract
POD (multivariable logistic regression)
Odds ratio (95% CI)P value
AIPmultivariable regression
1.622(1.455–1.81)
P < 0.001Higher AIP quartilequartile stratification
1.708(1.399–2.088)
P < 0.001AIPfully adjusted model (Model 3)
1.435(1.249–1.652)
P < 0.001Observational data: associations, not effects.
Further findings
Nonlinearity (restricted cubic spline (RCS))
- Significant nonlinear relationship between AIP and postoperative delirium (POD), consistent across gender subgroups
- P < 0.001
Subgroup analysis
- No significant interactions
Mediation analysis
- Hemoglobin (Hb), RDW, albumin and respiratory rate partially mediated the AIP–POD association
Original publication
The association between atherogenic index of plasma and postoperative delirium in cardiac surgery patients: an analysis of the MIMIC-IV database. Perioper Med (Lond). Published 8 July 2026. doi:10.
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