Association between combination antibiotic therapy as opposed as monotherapy and outcomes of ICU patients with Pseudomonas aeruginosa ventilator-associated pneumonia: an ancillary study of the iDIAPASON trial
Authors' conclusion
Except longer durations of antibiotic therapy and mechanical ventilation, potentially related to increased difficulty in achieving clinical cure, the patients in the combination therapy group had similar outcomes to those in the monotherapy group.
Study context
- Population
- ICU patients with Pseudomonas aeruginosa VAP randomised in the iDIAPASON trial (8 vs 15 days) who received appropriate antibiotic therapyincluded in the analysis
- Participants
- 169 patients
- Comparison
- Combination antibiotic therapy vs monotherapy
- Primary endpoint
- Mortality rate
- Follow-up
- Day 90
Methodological detailsancillary study, multicentre, Median duration of appropriate antibiotic therapy 14 days
- Ancillary study
- Multicentre
- Median duration of appropriate antibiotic therapy 14 days
Primary result
As reported in the abstract
Deaths at day 90
Combination therapy
20
events
Monotherapy
17
events
P = 0.180
Further findings
Duration of mechanical ventilation
P = 0.0243
- Duration of mechanical ventilation: results similar after adjustment for iDIAPASON randomisation arm and SOFA score at ICU admission
VAP recurrence, extra-pulmonary infections, multidrug-resistant (MDR) bacteria acquisition during ICU stay
- Similar with monotherapy and combination therapy
Original publication
Association between combination antibiotic therapy as opposed as monotherapy and outcomes of ICU patients with Pseudomonas aeruginosa ventilator-associated pneumonia: an ancillary study of the iDIAPASON trial. Crit Care. Published 30 May 2023. doi:10.
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