Association between early nutrition support and 28-day mortality in critically ill patients: the FRANS prospective nutrition cohort study
Authors' conclusion
In this prospective cohort study, early nutrition support in the ICU was significantly associated with increased mortality at D28, particularly in younger patients with less severe disease.
Study context
- Population
- Adults with predicted intensive care unit (ICU) LOS > 3 days, 26 ICUs in France and Belgium, 2015
- Participants
- 1,206 adults · 26 ICUs
- Exposure
- Early nutrition support vs no early nutrition
- Early nutritionn = 718
- Outcome
- Mortality
- Follow-up
- Day 28
Methodological detailsmulticentre, propensity-score-weighted, Retrospectively registered on November 5th 2015
- Multicentre
- Propensity-score-weighted
- Retrospectively registered on November 5th 2015
Main finding
As reported in the abstract
D28 mortality · D28
Early nutrition vs No early nutritionEstimate (95% CI)
Univariate analysis
crude OR 1.69(1.23–2.34)
Propensity-weighted multivariate analysis
aOR 1.05(1.00–1.10)
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| D28 mortality by route (early enteral / early parenteral vs no early nutrition)Early enteral nutrition vs No early nutrition | 1.06 (1.01–1.11) | |
| D28 mortality by route (early enteral / early parenteral vs no early nutrition)Early parenteral nutrition vs No early nutrition | 1.04 (0.98–1.11) | |
| 0.512Adjusted odds ratio (log scale) |
D28 mortality (subgroups)
- Association stronger in patients ≤ 65 years and with SOFA scores ≤ 8
Original publication
Association between early nutrition support and 28-day mortality in critically ill patients: the FRANS prospective nutrition cohort study. Crit Care. Published 7 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →