The association between increasing fluid balance, acute kidney injury and mortality in patients with sepsis and septic shock: A retrospective single center audit
Authors' conclusion
In patients with sepsis and septic shock, a more positive fluid balance is associated with an increased incidence of acute kidney injury and death after correction for possible confounders.
Study context
- Population
- ICU patients treated for sepsis or septic shock
- Participants
- 482 patients
- Exposure
- Non-survivors vs survivors; cumulative fluid balance on days 1 and 3
- Outcome
- Association of positive fluid balance with AKI and ICU mortality
Methodological detailssingle-centre, chart review
- Single-centre
- Chart review
Main finding
As reported in the abstract
ICU mortality and AKIN stage III by fluid balance on day 3 (logistic regression) · Day 3
Odds ratio
1.007
P = 0038
ICU mortality; independently associated
Odds ratio
1.006
P = 0.031
AKIN stage III; independently associated
Observational data: associations, not effects.
Further findings
Cumulative fluid balance · Day 1
P < 0.001
Cumulative fluid balance · Day 3
P = 0.005
Cumulative fluid balance · Day 1
- Fluid input did not differ; output differed significantly
Original publication
The association between increasing fluid balance, acute kidney injury and mortality in patients with sepsis and septic shock: A retrospective single center audit. J Crit Care. Published 25 July 2023. doi:10.
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