Net albumin leakage in patients in the ICU with suspected sepsis. A prospective analysis using mass balance calculations
Authors' conclusion
This study demonstrated a net positive albumin leakage of 8 ± 10 g over 24 h in ICU patients with suspected sepsis, with a weak early correlation to pro-inflammatory cytokines but no significant link to fluid balance or glycocalyx shedding.
Study context
- Population
- ICU patients within 12 h of admission for suspected sepsis, Karolinska University Hospital Huddinge
- Participants
- 10 patients
- Outcome
- Net albumin leakage (NAL) estimated by mass balance calculations
- Follow-up
- 24 h
Methodological detailssingle-centre, mass balance calculations
- Single-centre
- Mass balance calculations
Main finding
As reported in the abstract
Net albumin leakage to the interstitium
Net positive albumin leakage, g (± as printed)
8 ± 10 g
p = 0.029
Observational data: associations, not effects.
Further findings
Association of net albumin leakage (NAL) with glycocalyx shedding products, fluid overload and cytokines
- No correlation with glycocalyx shedding products or fluid overload
- Weak correlation with interleukin-6 and interleukin-8 in the first 4 h
Factors associated with NAL
- Albumin infusions appeared to increase net leakage
Original publication
Net albumin leakage in patients in the ICU with suspected sepsis. A prospective analysis using mass balance calculations. Crit Care. Published 8 March 2025. doi:10.
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