Association between intrarenal venous flow from Doppler ultrasonography and acute kidney injury in patients with sepsis in critical care: a prospective, exploratory observational study
Authors' conclusion
IRVF patterns were not associated with CVP but were associated with subsequent AKI in critically ill adult patients with sepsis.
Study context
- Population
- Adults with sepsis in ICU ≥24 h with central venous catheters and invasive mechanical ventilation, after sepsis resuscitation
- Participants
- 38 adults
- Exposure
- Discontinuous vs continuous intrarenal venous flow pattern
- Discontinuousn = 22
- Outcome
- Central venous pressure (CVP) at the time of renal ultrasonography
Methodological detailsexploratory, two tertiary-care hospitals, blinded assessor, Sample size of 32 set to detect a 5-mmHg difference in central venous pressure (CVP)
- Exploratory
- Two tertiary-care hospitals
- Blinded assessor
- Sample size of 32 set to detect a 5-mmHg difference in CVP
Main finding
As reported in the abstract
CVP
Discontinuous
9.24
mean · SD 3.19 · cm H2O
Continuous
10.65
SD 2.53 · cm H2O
P = 0.154
Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Composite of KDIGO stage 3 AKI or death · over the course of a weekGeneralized estimating equation | 9.67 (2.13–44.03) | P = 0.003 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Association between intrarenal venous flow from Doppler ultrasonography and acute kidney injury in patients with sepsis in critical care: a prospective, exploratory observational study. Crit Care. Published 10 July 2023. doi:10.
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