Hemodynamics, fluids & transfusion
Association between mean hemodynamic variables during the first 24 h and outcomes in cardiogenic shock: identification of clinically relevant thresholds
Authors' conclusion
This study is the first to identify critical hemodynamic thresholds, encompassing both macrocirculatory and tissue perfusion variables, within the initial 24 h of CS that are associated with adverse outcomes.
Study context
- Population
- Patients with cardiogenic shock (CS)enrolled 2011–2021
- Participants
- 118 patients
- Comparison
- Mean hemodynamic variables over first 24 h in patients with vs without 30-day mortality
- Primary endpoint
- 30-day mortality
- Follow-up
- 30 days
Methodological detailsOptimaCC and MicroShock, prospective cohorts, Hemodynamic variables assessed at admission, 6, 12, and 24 h
- OptimaCC and MicroShock
- Prospective cohorts
- Hemodynamic variables assessed at admission, 6, 12, and 24 h
Primary result
As reported in the abstract
30-day mortality
37%
Further findings
Clinically relevant thresholds of first 24 h for poor outcomes
- Mean SAP
- < 95 mmHg
- Mean arterial pressure (MAP)
- < 70 mmHg
- Cardiac output (CO)
- < 3.5 L/min
- Cardiac index
- ≤ 1.8 L/min/m²
- Cardiac power index
- < 0.27 W/m²
- ScvO2
- < 70%
- ΔPCO2
- ≥ 9 mmHg
- ΔPCO2/C(a-v)O2
- ≥ 1.5 mmHg/mL
Original publication
Association between mean hemodynamic variables during the first 24 h and outcomes in cardiogenic shock: identification of clinically relevant thresholds. Crit Care. Published 26 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →